Best Long-Term Weight Loss Programme | Keto Long Term Success

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Finding a Weight Loss Journey That Lasts

You may have tried diet after diet, only to see the weight creep back on again—leaving you disheartened, frustrated, and unsure if long-term success is even possible. You are not alone. Support is just a phone call away. At PronoKal, we understand that true well-being isn’t just about numbers on a scale—it’s about feeling confident, energetic, and proud of what you have achieved. It is also about having faith in the future.

That’s why our long-term weight loss programme is designed to support real people, with real lives, facing the challenges of the food environment in which we live. In addition to its excellent weight loss effects, the PnK programme includes a 2-year follow-up to help you keep the weight off, so important to self-confidence as well as to the prevention and treatment of long-term health conditions—protecting against future risks while improving possible existing health concerns. Above all, it’s a flexible, personalised approach that meets you where you are today, and helps you move forward with conviction.

With expert medical support, nutritional guidance, and long-term lifestyle strategies, PronoKal makes sustainable change possible. Here, lasting success begins with empathy, evolves through evidence, and endures through empowerment.

Type 2 Diabetes

Our gut converts carbohydrates into sugars, mainly glucose. The amount of glucose in the blood is controlled by a hormone called insulin, released by the pancrease. Insulin helps glucose enter the cells. When are cells have enough glucose, any excess is stored in our liver and muscles. And once they are full, any left-over glucose is turned into fat.

If you have type 2 diabetes, your body doesn’t respond correctly to insulin regulation (insulin resistance), and the levels of glucose in your blood will rise. This can cause a range of serious complications, including kidney disease, peripheral neuropathy (nerve damage), diabetic retinopathy (an eye condition that can lead to blindness), and an increased risk of heart attacks or strokes.

Insulin resistance can be managed effectively in many patients by making lifestyle and dietary changes. If you follow a very low calorie keto diet such as PronoKal’s PnK plan, your cells can become sensitive to the action of insulin again, and your body regains the ability to handle sugar efficiently and effectively. This will reduce the risk of developing diabetes or, if you have already developed the condition, the PnK programme could help you manage it better or even get you into diabetes remission.

Is it safe to do a keto diet if you have diabetes?

This depends on the type of diabetes you have and the medication you are using, if any, to control your blood sugar levels.

Type 1 diabetes: DO NOT USE KETOGENIC DIETS

Type 2 diabetes: Ketogenic diets are safe for most people with recently diagnosed type 2 diabetes controlled on diet and lifestyle.

If you have started medication, this will usually initially be metformin, which is not a contraindication for starting a keto diet. However, your doctor will probably have to reduce the dose as the diet itself brings your blood sugar levels under control.

Patients with type 2 diabetes who have been started on other blood-sugar-lowering medication (eg. insulin, sulphonylureas, SGLTs inhibitors) MUST NOT initiate a ketogenic diet without speaking to their doctor, as the medication will need to be changed.

Can PronoKal put my diabetes into remission?

A clinical trial called the DiRECT trial showed that almost half of participants with type 2 diabetes of recent onset (less than 6 years since diagnosis) who lost more than 15 kg achieved remission of their diabetes using a low-calorie meal replacement diet.

Another trial published the same year also achieved diabetes remission using a ketogenic diet without calorie restriction in patients with type 2 diabetes without limiting the time since diagnosis.

PronoKal, which has been shown to be safe in patients with type 2 diabetes, combines these two approaches in its very low calorie ketogenic diet.

If a keto diet puts my diabetes into remission, will I need to stay on it forever?

No, you don’t have to live in ketosis. The PronoKal very low calorie keto diet helps to restore metabolic health, and that can then be maintained by sticking to a healthy balanced diet that avoids refined carbohydrates and ultra-processed foods and that enables you to remain weight stable. We will help you find the healthy balanced diet that suits you and keeps you weight stable for the long term.

That said, some people choose to continue in nutritional ketosis, with evidence of a sustained improvement in their diabetic disease.

Dyslipidaemia and Cardiovascular Conditions

Our blood naturally contains two types of fat (or "lipids"). The first is cholesterol, which comes in two main forms:

1. LDL-cholesterol (or "bad cholesterol") - Too much of this indicates an increased risk of developing atherosclerosis. This is a condition in which plaque builds up within your arteries, restricting blood flow. Atherosclerosis can be a contributory factor in conditions such as angina, coronary heart disease, and peripheral arterial disease.

2. HDL-cholesterol (or "good cholesterol") - If you have healthy levels of this in your blood, it will help to reduce the damage that can be caused by "bad cholesterol" by taking the cholesterol back to your liver to be broken down. This will reduce the risk that you will develop atherosclerosis and associated cardiovascular conditions.

The second type of blood fat is triglycerides. Our bodies convert excess calories from food into triglycerides and store them away to use later as energy. However, if our triglyceride levels are too high, they can cause the same type of issues as high LDL-cholesterol.

Switching to a ketogenic diet can reduce the levels of "bad cholesterol" and triglycerides in your system, and can also boost the amount of "good cholesterol" in your blood. This will help to reduce your risk of developing life-threatening cardiovascular conditions.

Is it true that ketogenic diets increase LDL-cholesterol?

There are many types of ketogenic diet, some of which include large amounts of fat. These can elevate LDL-cholesterol.

The PronoKal PnK programme uses a very low fat diet. In a study by the European Association for the Study of Obesity, this approach was shown not to elevate LDL-cholesterol.

Can ketogenic diets help in familial hypercholesterolaemia?

Familial hypercholesterolaemia (FH) is a genetic condition associated with high or very high cholesterol levels in the blood and with an elevated risk of heart disease. FH does not typically respond effectively to dietary approaches, and medication is needed to achieve control.

If I have established fatty liver, can a keto diet help?

Yes, clinical studies and reviews show that fatty liver responds very well to ketosis, which plays a pivotal role in stimulating key factors in liver protection through stimulating insulin sensitivity and reducing inflammation.

If ketosis resolves my fatty liver, will I have to stay in ketosis forever?

No, the liver has excellent regenerative properties and can recover completely or almost completely from fatty infiltration. Be aware that recovery is more difficult in more advanced disease; this can be assessed using special liver scans.

Once liver function returns to normal or near normal, you do not need to remain in ketosis. However, it is essential to stick to a healthy balanced diet that protects liver function and metabolic health in the long term. The PronoKal team will help you achieve this.

Obesity-Related Inflammation – The Cause of Many Obesity-Related Diseases

Scientific studies have shown that obesity induces low-grade inflammation. Not only does this make it harder to achieve and maintain weight loss, but inflammation is recognised as the link between obesity and many chronic diseases.

The keto diet helps to reduce inflammation through weight loss and the formation of beta-hydroxybutyrate, one of the ketone bodies produced when we burn fat. The PronoKal diet, in addition, has specific ingredients with anti-inflammatory properties.

Are there any other causes of low-grade inflammation?

The two main causes of low-grade inflammation are a poor diet and obesity, which often go hand-in-hand. A poor diet alters the gut microbiome, the microbial community that lives in our gut and that is essential for gut health. Alterations of the gut microbiome lead to disruption of the lining of the gut, provoking low-grade inflammation. From the gut, this inflammation can spread to other tissues.

The changes that occur in the adipose (fat) tissue, such as oversized fat cells and poor blood supply, also stimulate inflammation.

How do I know if I have low-grade inflammation?

Low-grade inflammation is different from the acute inflammation you see, for example, after an insect bite or sting. Acute inflammation is painful and red and swollen. Low-grade inflammation does not cause these symptoms. However, it does provoke changes that develop gradually, and those changes do cause changes, which can be serious. Inflammation drives weight gain. It also drives many of the diseases associated with weight gain, such as diabetes and liver or heart disease. Some blood tests can be suggestive of low-grade inflammation. Your doctor will test for these if there is an indication to do so.

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